Screening Facilities
CO-ADD Screening facilities include
- Robotic Screening Equipment
- Microbiology Facility
- Cell Biology Facility
- Compound Handling Facilities for medium to high throughput screening
These facilities are located at The University of Queensland's Institute for Molecular Bioscience in Brisbane, Australia.
CO-ADD contains a growing collection of more than 350 bacterial and fungal strains, encompassing ATCC reference sensitive strains, a range of clinical isolates from around the world, multidrug-resistant strains, and genetically modified strains. Standard minimum inhibitory concentration (MIC) testing is conducted in 96-well plates, or in high-throughput format in 384-well plates in two dedicated BSL-2 secure facilities.
Which are complemented with
- Medicinal Chemistry Lab
- Molecular and Cellular Proteomics Mass Spectrometry Facility
- UQROCX - UQ Remote Operation Crystallization and X-ray Diffraction Facility
- CMM - The Centre for Microscopy and Microanalysis
- AMMRF - Queensland Node of the Australian Microscopy and Microanalysis Research Facility
- Queensland Centre for Medical Genomics
- QFAB - Queensland Facility for Advanced Bioinformatics
Medicinal Chemistry and Efficacy
CO-ADD is equipped with a fully functional medicinal chemistry lab, comprising analytical and purification equipment.
- Analytical LC/MS (ELSD)
- Preparative HPLC
- Rotational Vacuum Concentrator (RVC)
- Analytical NMR
- Robotics for liquid handling
- Murine efficacy models
Which are complemented with
The fully equipped lab enables CO-ADD to provide:
- Synthesis of individual ligands up to a scale of 1g
- Synthesis of chemical libraries up to a size of 500 compounds per library
- Pre-clinical efficacy studies