‘Forgotten’ antibiotic offers hope against worst superbugs

An antibiotic overlooked since its discovery 40 years ago could help develop new drugs against life-threatening infections caused by some of the world’s most dangerous superbugs.

University of Queensland Institute for Molecular Bioscience (IMB) researchers synthesised the antibiotic, and increased its effectiveness against extensively drug-resistant bacteria, then collaborated with Monash University to evaluate the drug using animal models of infection.

An extra membrane camouflages Gram-negative bacteria from drugs and the immune system.